Recent Publications

Mouse. Small axons left without compact myelin in Teneurin-4 knockouts still survive at a year; four 14-3-3 isoforms rise in them, and blocking 14-3-3 hastens their damage.

Comprehensive review of OPC roles beyond myelin repair: regulation of neuronal circuit activity, immune surveillance, vascular remodelling, and metabolic support

H3K27M histone mutation sustains OPC-like stemness in DIPG organoids; blocks normal OPC maturation and creates targetable epigenetic vulnerability

Review of bidirectional signalling between oligodendrocyte lineage cells and microglia, astrocytes and peripheral immune cells in MS lesion evolution

Neuroligin-3 binds NG2/CSPG4 on OPCs to activate integrin-mediated mechanotransduction, sustaining progenitor state; the same pathway is co-opted by glioma

Abeta1-42 oligomers impair OPC viability, migration and differentiation capacity in culture; also disrupts tight junction proteins in BBB endothelia

Oridonin stabilises HIF-1alpha in OPCs by inhibiting PHD2-mediated ubiquitination, driving VEGF secretion and vessel sprouting after stroke

Review of hydrogel, nanoparticle and scaffold systems for sustained delivery of remyelinating agents in spinal cord injury; discusses OPC recruitment strategies

Bergles lab: oligodendrocytes wrap axons with flexible sheaths, enabling myelination across geometrically complex networks; live imaging in mouse cortex

Bergles lab: cell atlas of the oligodendrocyte lineage across the whole mouse brain; regional differences in OPC density and turnover; myelin injury map

SCN2A gain-of-function drives premature oligodendrocyte maturation and hypermyelination in mouse models of epileptic encephalopathy

Blood EV markers (MOG, MBP surface) elevated after repetitive subconcussive impacts; potential biomarker of oligodendrocyte stress

Human iPSC-derived spinal cord organoids produce OPCs and oligodendrocytes matching in vivo transcriptomic signatures; disease states modelled

MSL2 histone methyltransferase controls OPC proliferation; loss causes white matter hypoplasia and autism-like phenotype in mice

Human post-mortem. MSA oligodendrocytes carry more somatic SNCA gains than controls (6.3% vs 2.0%); a gain doubles the chance of an alpha-synuclein inclusion in that cell and tracks earlier onset.

Human mid-gestational neocortex. Maps chromatin looping, accessibility and methylation in four glial populations including OPCs, and prioritises 112 schizophrenia risk variants sitting in glial regulatory elements.

Mouse. Halving Glut1 lowers brain glucose, glycogen and lactate, and in the striatum turns down oligodendrocyte and galactolipid genes and depletes myelin-enriched lipids.

Rat CSVD model. Histology and transcriptomics documented myelin disruption alongside altered mature oligodendrocyte and OPC marker profiles, blood-brain barrier breakdown, and microvascular rarefaction at successive time points.

Review linking prenatal alcohol exposure to white matter damage via oligodendrocyte deficiency and impaired myelination, in FASD patients and animal models.

Mouse. Wild-type brainstem OPCs proliferate more slowly and differentiate later than telencephalic OPCs in culture, and the K27M glioma mutation exploits that regional difference.

Neonatal cortical injury model. OPCs from the subventricular zone reach a lesion by travelling with migrating neuroblasts, held by adherens junctions that form and dissolve as they go.

Single-cell RNA sequencing resolves the mouse oligodendrocyte lineage into distinct transcriptional states across brain regions.

Rat, culture and explant. Spinal cord oligodendrocytes generate longer internodes than cortical oligodendrocytes on identical fibres. Internode length differences between CNS regions are intrinsic to the oligodendrocyte, not instructed by the axon; the same regional identity is seen on microfibers, in co-culture, and in explants. Landmark paper establishing oligodendrocyte regional identity.

Myelin grows from the inner tongue outward; PI(3,4,5)P3 at the leading edge drives membrane extension beneath the previously deposited layers.

Comprehensive review of CNS and PNS myelination: sheath assembly, axon glia signalling, and the metabolic role of the oligodendrocyte. The modern structural reference.

MCT1 in oligodendrocytes exports lactate to axons. Deleting it causes axon degeneration with the myelin sheath still intact, separating support from insulation.

Disabling oxidative phosphorylation in oligodendrocytes does not cause demyelination; the cells run on aerobic glycolysis and pass the product to the axon.

Single-cell lineage tracing shows NG2 cell fate narrows with age, and that white matter NG2 cells keep producing oligodendrocytes into adulthood.

OPC recruitment, the differentiation block in chronic MS, g-ratio as a repair metric, and the therapeutic strategies that follow from each.

Full account of myelin composition and oligodendrocyte biology; the source for the 70 percent lipid, 30 percent protein figure.

Definitive description of the cuprizone model: dose, timing, lesion anatomy, and spontaneous recovery. The benchmark for later cuprizone work.

Identifies Olig1 and Olig2 as Shh-regulated bHLH transcription factors marking and specifying the oligodendrocyte lineage.

Transected axons are present in active MS plaques in proportion to inflammation, establishing axonal injury as an early event rather than a late one.

OPCs are present in chronic MS lesions but are not dividing or maturing. Remyelination failure is a differentiation block, not an absence of precursors.

NT-3 promotes OPC proliferation and survival; blocking it causes OPC death. A landmark in oligodendrocyte developmental biology.